Steroids and derivatives
Innovative Reseach Of America INNOVATIVE RESEARCH OF AMERICA
NC3903870 0.36 MG 17B ESTRADIOL PELLETS
Medchemexpress LLC Alpha-Estradiol-d2 | 81586-94-9 | 99.8% | 1 MG
Alpha-Estradiol-d2 is a deuterium-labeled version of Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and acts as a 5α-reductase inhibitor, used topically for treating androgenic alopecia. Stable heavy isotopes like deuterium are incorporated into drug molecules for use as tracers in drug development, and deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Estradiol-d5 | 221093-45-4 | 99.1% | 1 MG
Estradiol-d5 is a deuterium-labeled form of Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during the drug development process.
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 25 MG
Estradiol 3-methyl ether is a synthetic estrogen. It can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibits cell proliferation. Estradiol 3-methyl ether has also been shown to decrease serum cholesterol levels and increase body weight loss, indicating feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks in V79 cells (EC50 of 9 μM)
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss in HFD murine models
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 50 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. The compound is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, demonstrating potent and long-acting STS inhibition.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Increased estrone sulfatase inhibitory activity with specific halogen moieties.
- Readily absorbed and transformed in the gut into its oxidative metabolite, EMATE.
- Both compounds demonstrate potent and long-acting STS inhibition.
Alkali Scientific Digitonin, Water Soluble, 500 Milligrams
Digitonin is a water-soluble compound used primarily in membrane permeabilization for research applications. Available in a 500mg format, Digitonin is widely used in cell biology to permeabilize cell membranes, allowing researchers to study intracellular components or deliver compounds directly into cells. It is particularly useful in protein extraction, cellular signaling studies, and in assays that require the breakdown of membrane integrity without damaging the cells entirely. This high-purity product facilitates effective permeabilization while maintaining cellular viability, making it essential for research on cellular processes, membrane proteins, and intracellular interactions.
Medchemexpress LLC β-Estradiol 17-hemisuccinate | 7698-93-3 | 98.8% | 372.45 | 1 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol, classified as a drug derivative. It is intended for research applications.
- Synthetic derivative of estradiol
- Molecular formula: C22H28O5
- Molecular weight: 372.45
- Purity: 98.83% (LCMS)
- Appearance: White to off-white solid
- Storage: 4°C, stored under nitrogen
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (stored under nitrogen)
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 500mg
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Medchemexpress LLC Alpha-Estradiol (Standard) | 57-91-0 | 99.93% | 25 MG
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol, intended for research and analytical applications. It is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia.
- Reference standard supplied assay
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
Sigma Aldrich Fine Chemicals Biosciences -Estradiol-Water Soluble BioReagent, suitable for cell culture, MFCD00133134
-Estradiol-Water Soluble BioReagent, suitable for cell culture
Sigma Aldrich Fine Chemicals Biosciences alpha Estradiol powder 98500MG
alpha Estradiol powder 98500MG
Medchemexpress LLC Estradiol dipropionate | 113-38-2 | 99.5% | 50 MG
Estradiol dipropionate is a combined estrogen-progesterone that acts as an estrogen and progesterone agonist. It is for research use only and not sold to patients.
- Acts as an estrogen and progesterone agonist.
- Suitable for in vivo studies.
- Used in research for metabolic or endocrine disease.
Medchemexpress LLC Estradiol 17-(β-D-Glucuronide) sodium | 15087-02-2 | 98.9% | 50 MG
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. It functions as a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). This compound regulates and inhibits MRP8-mediated transport processes and can be used in studies related to intrahepatic cholestasis, as it induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats.
- Metabolite of natural estrogen
- Substrate of Oatp and Mrp2
- Regulates and inhibits MRP8-mediated transport processes
- Induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis
- Useful in studies related to intrahepatic cholestasis
- Solid, white to off-white appearance
- Molecular weight of 470.49
- Chemical formula C24H31NaO8
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Cayman Chemical EstradIol CypIonate 1g
A synthetic estrogen; reduces estrogen-depletion induced spikes in basal tail temperature in ovariectomized wild-type, ERα-/-, and ERβ-/- mice at 0.1 mg/kg per day; increases the rate of pregnancy in cows induced to ovulate small dominant follicles; reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis